What is gastroparesis?

Gastroparesis is a condition that affects the movement of food and liquid from your stomach into your small intestine. In a person with gastroparesis, the stomach does not empty regularly like it is supposed to. This is called delayed stomach emptying.

What is diabetic gastroparesis?

Diabetic gastroparesis is gastroparesis caused by diabetes. People with either type 1 or type 2 diabetes can develop gastroparesis, but people with type 1 diabetes are at higher risk. Women are also 4X more likely to develop diabetic gastroparesis than men.

What are the symptoms of diabetic gastroparesis?

The most common symptoms of diabetic gastroparesis are nausea, vomiting, bloating, stomach pain, and early satiety (feeling full quickly after eating a small amount).

How does GIMOTI work?

GIMOTI is a nasal spray that delivers medicine directly into your bloodstream. GIMOTI is used in adults for the relief of diabetic gastroparesis symptoms.

How is GIMOTI different from medicines that are taken by mouth?

Medicines taken by mouth have to be emptied from the stomach into the small intestine before they can be absorbed into the body and start working. Medicines in the form of a nasal spray can bypass the stomach to start working even if you are feeling nauseated or vomiting.

What do I need to know about using a nasal spray?

GIMOTI is a fine mist that delivers medication through your nose. Among 98 patients who were interviewed after participating in a clinical trial for GIMOTI, 96% found metoclopramide nasal spray easy to use,† even if they had never used a nasal medication before. Learn how to use GIMOTI.

I have tried metoclopramide in pill form before. How is GIMOTI different?

Metoclopramide pills may sit in the stomach for hours without being absorbed, which may impact their ability to provide symptom relief. On the other hand, some people with diabetic gastroparesis may not even be able to take pills in the first place because they experience nausea and vomiting. Because GIMOTI is a nasal spray, it delivers the medicine through your nose directly into your bloodstream—instead of through your stomach like a pill. With GIMOTI, absorption and symptom relief are not affected by delayed stomach emptying, nausea, or vomiting. If pills have not offered you symptom relief, you may want to ask your doctor about GIMOTI.

Who should not take GIMOTI?

GIMOTI is not recommended for use in children. It is important you speak to your doctor to see if GIMOTI is right for you. Do not use GIMOTI if you: Have a history of tardive dyskinesia or have a problem controlling your muscles and movements after taking GIMOTI or a medicine that works like GIMOTI. Have stomach or intestinal problems that could get worse with GIMOTI, such as: bleeding, blockage, a tear in the stomach or bowel wall. Have a type of tumor that can cause high blood pressure, such as pheochromocytoma. Have epilepsy (seizures). Are allergic to metoclopramide. Stop taking GIMOTI right away and get emergency help if you have any of these symptoms: Swelling of your tongue, throat, lips, eyes, or face. Trouble swallowing or breathing. Skin rash, hives, sores in your mouth, or skin blisters

What are the possible serious side effects of GIMOTI?

TARDIVE DYSKINESIA, abnormal muscle movements, mostly in the face and tongue muscles. You cannot control these movements, and they may not go away even after stopping GIMOTI. Your chances of getting tardive dyskinesia increase. The longer you take metoclopramide and the more metoclopramide you take. You should not take GIMOTI for more than 12 weeks at a time. If you are older, especially if you are an older woman. If you have diabetes

What are the most common side effects of GIMOTI?

Unpleasant taste after dosing, headache, and tiredness.

Is there a financial savings program for GIMOTI?

Yes, if you have commercial insurance (private insurance that you get from your employer or buy for yourself), you may be eligible for a $0 or $20 copay on GIMOTI. Learn more.

You can only get GIMOTI by prescription and through ASPN Pharmacies. Learn more.

How do I start a conversation about GIMOTI with my doctor?

If you have gastroparesis and still experience symptoms after making diet changes and/or taking medicine, talk to your doctor about GIMOTI as a treatment option. Get a personalized discussion guide to help you with the conversation!

How do I get more information about GIMOTI?

Contact one of our service representatives at 1-833-4-GIMOTI (1-833-444-6684).

Frequently asked questions

: Gastroparesis is a condition that affects the movement of food and liquid from your stomach into your small intestine. In a person with gastroparesis, the stomach does not empty regularly like it is supposed to. This is called "delayed stomach emptying."¹
: Diabetic gastroparesis is gastroparesis caused by diabetes. People with either type 1 or type 2 diabetes can develop gastroparesis, but people with type 1 diabetes are at higher risk. Women are also 4X more likely to develop diabetic gastroparesis than men.²
: The most common symptoms of diabetic gastroparesis are nausea, vomiting, bloating, stomach pain, and early satiety (feeling full quickly after eating a small amount).³
: GIMOTI is the only nasal spray for the treatment of diabetic gastroparesis symptoms. Unlike pills, GIMOTI is not affected by delayed stomach emptying and may be easy to take even if you experience vomiting or feel nauseated.⁴
If you are suffering from symptoms of diabetic gastroparesis, talk to a doctor about GIMOTI.

GIMOTI is a prescription medicine used for 2 to 8 weeks for the relief of symptoms in adults with diabetes who have irregular or slow stomach emptying. GIMOTI is not recommended for use in children. Avoid treatment with metoclopramide (all dosage forms and routes of administration) for longer than 12 weeks because of the increased risk of developing tardive dyskinesia with longer-term use.⁵
: GIMOTI is a nasal spray that delivers medicine directly into your bloodstream. GIMOTI is used in adults for the relief of diabetic gastroparesis symptoms.⁵
: Medicines taken by mouth have to be emptied from the stomach into the small intestine before they can be absorbed into the body and start working. Medicines in the form of a nasal spray can bypass the stomach to start working even if you are feeling nauseated or vomiting.⁴
: GIMOTI is a fine mist that delivers medication through your nose. Among 98 patients who were interviewed after participating in a clinical trial for GIMOTI, 96% found metoclopramide nasal spray easy to use,^† even if they had never used a nasal medication before.⁶ Learn how to use GIMOTI.

†Of these patients, 65% found nasal metoclopramide extremely easy to use while 31% found it somewhat easy to use.⁶
: Metoclopramide pills may sit in the stomach for hours without being absorbed, which may impact their ability to provide symptom relief. On the other hand, some people with diabetic gastroparesis may not even be able to take pills in the first place because they experience nausea and vomiting.^7,8
Because GIMOTI is a nasal spray, it delivers the medicine through your nose directly into your bloodstream—instead of through your stomach like a pill. With GIMOTI, absorption and symptom relief are not affected by delayed stomach emptying, nausea, or vomiting.^4,8
If pills have not offered you symptom relief, you may want to ask your doctor about GIMOTI.
: GIMOTI is not recommended for use in children.⁵ It is important you speak to your doctor to see if GIMOTI is right for you.
Do not use GIMOTI if you:
Have a history of tardive dyskinesia or have a problem controlling your muscles and movements after taking GIMOTI or a medicine that works like GIMOTI
Have stomach or intestinal problems that could get worse with GIMOTI, such as:
bleeding
blockage
a tear in the stomach or bowel wall
Have a type of tumor that can cause high blood pressure, such as pheochromocytoma
Have epilepsy (seizures)
Are allergic to metoclopramide
Stop taking GIMOTI right away and get emergency help if you have any of these symptoms:
Swelling of your tongue, throat, lips, eyes, or face
Trouble swallowing or breathing
Skin rash, hives, sores in your mouth, or skin blisters
: TARDIVE DYSKINESIA, abnormal muscle movements, mostly in the face and tongue muscles. You cannot control these movements, and they may not go away even after stopping GIMOTI. Your chances of getting tardive dyskinesia increase
The longer you take metoclopramide and the more metoclopramide you take. You should not take GIMOTI for more than 12 weeks at a time.
If you are older, especially if you are an older woman
If you have diabetes
: Unpleasant taste after dosing, headache, and tiredness.^5,6
: Yes, if you have commercial insurance (private insurance that you get from your employer or buy for yourself), you may be eligible for a $0 or $20 copay on GIMOTI.^* Learn more.
: You can only get GIMOTI by prescription and through ASPN Pharmacies. Learn more.
: If you have gastroparesis and still experience symptoms after making diet changes and/or taking medicine, talk to your doctor about GIMOTI as a treatment option. Get a personalized discussion guide to help you with the conversation!
: Contact one of our service representatives at 1-833-4-GIMOTI (1-833-444-6684).

References: 1. The NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting. Neurogastroenterol Motil. 2013;25(5):427-438. 2. Krishnasamy S, Abell TL. Diabetic gastroparesis: principles and current trends in management. Diabetes Ther. 2018;9(Suppl 1):1-42. 3. Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L. Clinical guideline: management of gastroparesis. Am J Gastroenterol. 2013;108(1):18-37. 4. Gajendran M, Sarosiek I, McCallum R. Metoclopramide nasal spray for management of symptoms of acute and recurrent diabetic gastroparesis in adults. Expert Rev Endocrinol Metab. 2021;16(2):25-35. 5. Gimoti^® (metoclopramide) nasal spray [prescribing information]. Solana Beach, CA: EVOKE PHARMA^®. 2021. 6. Data on file. EVOKE PHARMA^®. 7. Ozsoy Y, Gungor S. Nasal route: an alternative approach for antiemetic delivery. Expert Opin Drug Deliv. 2011;8(11):1439-1453. 8. Parkman HP, Carlson MR, Gonyer D. Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet. Neurogastroenterol Motil. 2014;26(4):521-528.

Discover the GIMOTI difference

*Patients are not eligible for copay assistance if they are enrolled in any state or federally funded healthcare programs, such as Medicare and Medicaid, or where prohibited by law. Certain eligibility criteria apply; for Terms and Conditions, please visit gimotirx.com/terms.

IMPORTANT SAFETY INFORMATION

What is Gimoti^® (metoclopramide) nasal spray?

GIMOTI is a prescription medicine used 30 minutes before meals and at bedtime for 2 to 8 weeks to relieve symptoms of slow stomach emptying in adults with diabetes. Avoid treatment with metoclopramide (all dosage forms and routes of administration) for longer than 12 weeks.

GIMOTI is not recommended for use in children under age 18.

Important facts about GIMOTI

This is a summary of important information you need to know about GIMOTI. This information does not take the place of talking with your healthcare professional about your medical condition or your treatment.

What is the most important information I should know about GIMOTI?

GIMOTI can cause serious side effects, including: TARDIVE DYSKINESIA: Abnormal muscle movements, mostly of the face or tongue muscles. You cannot control these movements, and they may not go away even after stopping GIMOTI. Your chances of getting tardive dyskinesia increase

The longer you take metoclopramide and the more metoclopramide you take. You should not take GIMOTI for more than 8 weeks at a time, and you should not take products containing metoclopramide (including GIMOTI) for more than 12 weeks at a time.
If you are older, especially if you are an older woman (e.g., age 65 years and older)
If you have diabetes

Call your healthcare professional right away if you get movements you cannot stop or control, such as lip smacking, chewing, or puckering up your mouth; frowning or scowling; sticking out your tongue; blinking and moving your eyes; shaking of your arms and legs.

Do not use GIMOTI if you

Have a history of tardive dyskinesia or have a problem controlling your muscles and movements after taking GIMOTI or a medicine that works like GIMOTI
Have stomach or intestinal problems that could get worse with GIMOTI, such as bleeding, blockage, or a tear in the stomach or bowel wall
Have a type of tumor that can cause high blood pressure, such as pheochromocytoma
Have epilepsy (seizures)
Are allergic to metoclopramide. Stop taking GIMOTI right away and get emergency help if you have any of these symptoms:
- swelling of your tongue, throat, lips, eyes, or face
- trouble swallowing or breathing
- skin rash, hives, sores in your mouth, or skin blisters

Before starting GIMOTI, tell your healthcare professional about all your medical conditions, especially if you have

Problems controlling your muscle movements after taking any medicine
Parkinson’s disease
Pheochromocytoma
Kidney or liver disease
Depression or mental illness
High blood pressure

Also tell your healthcare professional if you are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed, or drink alcohol.

Tell your healthcare professional about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Speak with your healthcare professional before you start or stop any other medicines.

Especially tell your healthcare professional if you take

Another medicine that contains metoclopramide, such as REGLAN^® tablets
Medicine for Parkinson’s disease
Blood pressure medicine
Medicine for depression, especially a monoamine oxidase inhibitor (MAOI)
Antipsychotic medicine used to treat mental illness, such as schizophrenia
Insulin
Medicines that can make you sleepy, such as anxiety medicines, sleep medicines, and narcotics

What should I avoid while taking GIMOTI?

Do not drink alcohol while taking GIMOTI
GIMOTI may cause sleepiness or dizziness. Do not drive, operate machinery, or do potentially dangerous activities until you know how GIMOTI affects you

What are other possible side effects of GIMOTI?

Other changes in muscle control and movement, such as:
- uncontrolled spasms of your face and neck muscles, or muscles of your body, arms, and legs (dystonia)
- parkinsonism – slight shaking, body stiffness, and trouble moving or keeping your balance
- being unable to sit still or feeling that you need to move your hands, feet, or body (akathisia)
Neuroleptic Malignant Syndrome (NMS) – a very rare but very serious condition. NMS can lead to death and must be treated in a hospital
Depression, thoughts about suicide, and suicide
High blood pressure
Too much body water
Increased prolactin

Call your healthcare professional and get medical help right away if you

Feel depressed or have thoughts about hurting or killing yourself
Have high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and/or increased sweating
Have muscle movements that you cannot stop or control
Have muscle movements that are new or unusual

The most common side effects of GIMOTI include

Unpleasant taste after dosing
Headache
Tiredness

These are not all the possible side effects of GIMOTI. Ask your healthcare professional for medical advice about side effects.

You may report side effects related to Evoke Pharma products by calling 1-833-4-GIMOTI (1-833-444-6684) or emailing GIMOTImedinfo@evokepharma.com. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

This information should not take the place of you talking with your doctor or healthcare professional. If you have any questions about your condition, or if you would like more information about GIMOTI, talk to your doctor or pharmacist. Only you and your healthcare professional can decide if GIMOTI is right for you.

Please see complete Prescribing Information, including Boxed Warning, Medication Guide, and Instructions for Use.