Pills Don't Always Make Sense. Here's Why.

Diabetic gastroparesis can affect how your body absorbs any pills you take, possibly making these pills ineffective. Nasal sprays are not affected by diabetic gastroparesis because they are absorbed through the nose.¹

Taking a pill

Swallowing and keeping pills down can be difficult when you are experiencing nausea or vomiting²
Pills may sit in the stomach for hours without being absorbed, which may impact their ability to provide symptom relief¹
Unpredictable stomach emptying may cause pills sitting in your stomach to be absorbed by the body all at once, increasing the chance of side effects¹

Using a nasal spray

Your body absorbs the medicine through your nose, directly into your bloodstream¹
Absorption is not delayed or interrupted by unpredictable stomach emptying¹
Medication can be absorbed even if you are experiencing symptoms or flares³

†Based on answers from 98 patients with diabetic gastroparesis who were interviewed after a clinical trial for GIMOTI.

Learn about GIMOTI nasal spray

References: 1. Gajendran M, Sarosiek I, McCallum R. Metoclopramide nasal spray for management of symptoms of acute and recurrent diabetic gastroparesis in adults. Expert Rev Endocrinol Metab. 2021;16(2):25-35. 2. Ozsoy Y, Gungor S. Nasal route: an alternative approach for antiemetic drug delivery. Expert Opin Drug Deliv. 2011;8(11):1439-1453. 3. Parkman HP, Carlson MR, Gonyer D. Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet. Neurogastroenterol Motil. 2014;26(4):521-528. 4. Data on file. EVOKE PHARMA^®.

*Patients are not eligible for copay assistance if they are enrolled in any state or federally funded healthcare programs, such as Medicare and Medicaid, or where prohibited by law. Certain eligibility criteria apply; for Terms and Conditions, please visit gimotirx.com/terms.

IMPORTANT SAFETY INFORMATION

What is Gimoti^® (metoclopramide) nasal spray?

GIMOTI is a prescription medicine used 30 minutes before meals and at bedtime for 2 to 8 weeks to relieve symptoms of slow stomach emptying in adults with diabetes. Avoid treatment with metoclopramide (all dosage forms and routes of administration) for longer than 12 weeks.

GIMOTI is not recommended for use in children under age 18.

Important facts about GIMOTI

This is a summary of important information you need to know about GIMOTI. This information does not take the place of talking with your healthcare professional about your medical condition or your treatment.

What is the most important information I should know about GIMOTI?

GIMOTI can cause serious side effects, including: TARDIVE DYSKINESIA: Abnormal muscle movements, mostly of the face or tongue muscles. You cannot control these movements, and they may not go away even after stopping GIMOTI. Your chances of getting tardive dyskinesia increase

The longer you take metoclopramide and the more metoclopramide you take. You should not take GIMOTI for more than 8 weeks at a time, and you should not take products containing metoclopramide (including GIMOTI) for more than 12 weeks at a time.
If you are older, especially if you are an older woman (e.g., age 65 years and older)
If you have diabetes

Call your healthcare professional right away if you get movements you cannot stop or control, such as lip smacking, chewing, or puckering up your mouth; frowning or scowling; sticking out your tongue; blinking and moving your eyes; shaking of your arms and legs.

Do not use GIMOTI if you

Have a history of tardive dyskinesia or have a problem controlling your muscles and movements after taking GIMOTI or a medicine that works like GIMOTI
Have stomach or intestinal problems that could get worse with GIMOTI, such as bleeding, blockage, or a tear in the stomach or bowel wall
Have a type of tumor that can cause high blood pressure, such as pheochromocytoma
Have epilepsy (seizures)
Are allergic to metoclopramide. Stop taking GIMOTI right away and get emergency help if you have any of these symptoms:
- swelling of your tongue, throat, lips, eyes, or face
- trouble swallowing or breathing
- skin rash, hives, sores in your mouth, or skin blisters

Before starting GIMOTI, tell your healthcare professional about all your medical conditions, especially if you have

Problems controlling your muscle movements after taking any medicine
Parkinson’s disease
Pheochromocytoma
Kidney or liver disease
Depression or mental illness
High blood pressure

Also tell your healthcare professional if you are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed, or drink alcohol.

Tell your healthcare professional about all the medicines you take, including prescription drugs and over-the-counter medicines, vitamins, and herbal supplements.

Speak with your healthcare professional before you start or stop any other medicines.

Especially tell your healthcare professional if you take

Another medicine that contains metoclopramide, such as REGLAN^® tablets
Medicine for Parkinson’s disease
Blood pressure medicine
Medicine for depression, especially a monoamine oxidase inhibitor (MAOI)
Antipsychotic medicine used to treat mental illness, such as schizophrenia
Insulin
Medicines that can make you sleepy, such as anxiety medicines, sleep medicines, and narcotics

What should I avoid while taking GIMOTI?

Do not drink alcohol while taking GIMOTI
GIMOTI may cause sleepiness or dizziness. Do not drive, operate machinery, or do potentially dangerous activities until you know how GIMOTI affects you

What are other possible side effects of GIMOTI?

Other changes in muscle control and movement, such as:
- uncontrolled spasms of your face and neck muscles, or muscles of your body, arms, and legs (dystonia)
- parkinsonism – slight shaking, body stiffness, and trouble moving or keeping your balance
- being unable to sit still or feeling that you need to move your hands, feet, or body (akathisia)
Neuroleptic Malignant Syndrome (NMS) – a very rare but very serious condition. NMS can lead to death and must be treated in a hospital
Depression, thoughts about suicide, and suicide
High blood pressure
Too much body water
Increased prolactin

Call your healthcare professional and get medical help right away if you

Feel depressed or have thoughts about hurting or killing yourself
Have high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and/or increased sweating
Have muscle movements that you cannot stop or control
Have muscle movements that are new or unusual

The most common side effects of GIMOTI include

Unpleasant taste after dosing
Headache
Tiredness

These are not all the possible side effects of GIMOTI. Ask your healthcare professional for medical advice about side effects.

You may report side effects related to Evoke Pharma products by calling 1-833-4-GIMOTI (1-833-444-6684) or emailing GIMOTImedinfo@evokepharma.com. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

This information should not take the place of you talking with your doctor or healthcare professional. If you have any questions about your condition, or if you would like more information about GIMOTI, talk to your doctor or pharmacist. Only you and your healthcare professional can decide if GIMOTI is right for you.

Please see complete Prescribing Information, including Boxed Warning, Medication Guide, and Instructions for Use.